摘要
目的 观察Balb/C小鼠吸入烹调油烟 (cookingoilfumes ,COF)后肺组织的病理形态改变 ,研究COF的慢性毒性及其致癌性。方法 以Balb/C小鼠为实验对象 ,通过动式吸入染毒 8个月 (COF染毒浓度为 (9 0 9± 0 3 8) ,(2 0 65± 0 93 ) ,(3 8 85± 2 3 8)mg/m3 。共染毒 150次 ,每次染毒 3 0min ,制备COF染毒的慢性动物试验模型 ;对照组吸入加热空气 (2 2～ 3 0℃ )。用HE染色法观察鼠肺组织病理形态改变。结果 染毒组鼠肺组织病变以炎症改变为主 ,伴有肺泡上皮单纯性增生、腺样化生、腺瘤样增生、非典型增生和癌变 ,染毒组共有 2 8例呈肺腺癌改变 ,另有 1例为小细胞肺癌 ,诱癌率为 18 95%。对照组仅少数有炎症改变和单纯性增生。结论 COF能诱发Balb/C小鼠肺组织癌前病变及癌变。
ObjectiveTo study the chronic toxicity of cooking oil fu mes (COF),the pathological changes of lung tissues of Balb/C mice exposed to COF were observed. MethodsBalb/C mice were used to make chronic toxicity mo del.COF groups were exposed to COF of 3 kinds of different concentration [(9.09 ±0.38),(20.65±0.93),(38.85±2.38)mg/m\+3]for 150 times in eight months for 3 0?min each time.At the same time the control group inhaled heated air (22-30? ℃) for 150 times in eight months.HE stainning was used to study the pathologica l changes.ResultsThe main pathological changes of COF groups were characteristic of inflammation with alveolar epithelial hyperplasia,adenic metap lasia,adenomatoid hyperplasia and atypical hyperplasia.There were 28 cases of pu lmonary adenocarcinomata and 1 case of small cell carcinoma.In the control group ,none case of carcinoma was observed,only minority experimental animal had infla mmation and local mild epithelial hyperplasia.ConclusionPrecancerous lesion and canceration of lung ti ssues of Balb/C mice may be induced by COF;The carcinomata induced by COF were m ainly pulmonary adenocarcinoma.COF may be suspicious carcinogen to human.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2003年第12期1455-1457,共3页
Chinese Journal of Public Health
关键词
烹调油烟
BALB/C小鼠
肺腺癌
病理改变
动物/模型
cooking oil fumes
Balb/C mouse
pulmonary adeno carcinoma
pathological change
animal/model
