摘要
本文应用放射元疫方法测定了雌性大鼠侧脑室注射 P 物质及其拮抗剂后,在不同性周期中血清内的孕酮含量。以探讨 P 物质对大鼠卵巢孕酮生成的中枢性作用。以人工脑脊液做对照。在间情期,侧脑室注射 P 物质拮抗剂2μg/1μl,使血清孕酮水平明显增加;而在情前期和情期,侧脑室注射 P 物质1μg/1μl,引起血清孕酮明显降低。这些结果提示,P 物质可能在中枢水平对雌性大鼠孕酮生成具有调节作用。
Contents of serum progesterone were determined by radioimmunassay in fem tale rats and substance p and sp-antagonist were injected during diffrent sexual cycle through lateral brain ventricle to discuss the effect of the substance p on she progesterone genesis of the ovary in the central part.During the diestrus inj- ection of 2 μg/1 μl of sp-antagonist through lateral brain ventricle resulted in ignifieant increase in progesterone of the serum,during proestrus and estrus in jection of 1 μg/1μl of substance p resulted in significant deerease in progester- one of serum compared with injection of artificial cerebrospinal fluid in contro- lled animls. These results prove that the substance p may have effect of regulation in the central part on the progesterone genesis in female rats.
出处
《锦州医学院学报》
1989年第1期1-3,共3页
Journal of Jinzhou Medical College
关键词
P物质
血清
孕酮
Substance P Serum Progesterone Sp-Antagonist
