摘要
目的 对使用同济95-2方案治疗的非霍奇金淋巴瘤(NHL)患儿的肾功能进行监测,了解异环磷酰胺等药物对NHL患儿肾功能的近、远期影响。方法 采用自身对照法,通过测定血清BUN、Cr、Ccr、血、尿β2-MG、尿Alb、TRF、IgG、RBP等多项参数,对实施同济95-2方案的Ⅲ期B细胞型NHL患儿的肾功能进行全面评估。结果 10例NHL患儿完成同济95-2方案的长期和序贯治疗,均获CR。同化疗前比较,1例出现镜下血尿伴轻度蛋白尿,1例有一过性Ccr下降;2例有非肾小球性血尿;血、尿β2-MG及尿Alb、RBP显著升高(P<0.05),持续长期缓解逾3年的8例中3例仍有尿RBP升高。结论 含异环磷酰胺的同济95-2化疗方案对NHL患儿肾功能有一定程度的损害,以尿中RBP含量升高为主要标志的肾小管损害为主,大多数处于亚临床状态,多数可逆,少部分可长期存在。
Objective To investigate the renal damages in childhood non-Hodgkin' s lymphoma (NHL) who received chemotherapy of Tongji-95 protocol with ifosfamide involved. Methods 10 cases of consecutively diagnosed B cell stage Ⅲ NHL were inspected by multi-parameter assay including serum BUN、Cr、Ccr、β2-MG and urinary β2-MG、Alb、TRF、 IgG、NRBP. Results 10 cases of NHL children were received chemotherapy of Tongji 95-2 protocol,and all of them ac-quired complete remission. Glomerular microscopic hematuria and mild proteinuria presented in one child,non-glomerular hematuria in two children after the chemotherapy. Corresponding to the pre-chemotherapy the levels of serum BUN、Cr、 Ccr were normal in most children,blood β2-MG, urinary β2-MG,Alb and RBP increased significant(P<0. 05), the in-crease of urinary TRF、IgG were insignificant(P>05). Conclusion Variant degrees of renal damages occurred in the patients who receiving Tongji-95 protocol with ifosfamide involved. Among them,marked by alleviated urinary RBP, the tubular dysfunction was a major and irreversible damage,even if most of them stayed on subclinical status. Additionally, Osome of the damage continually occurred for a long time.
出处
《同济大学学报（医学版）》
CAS
2003年第6期506-508,共3页
Journal of Tongji University(Medical Science)
关键词
淋巴瘤
非霍奇金
化疗
异环磷酰胺
肾损害
non-Hodgkin's lymphoma
chemotherapy
ifosfamide
renal damage
