摘要
目的 :引起临床医师对头孢菌素导致双硫仑样反应的重视。方法 :对协和医院 2 0 0 3年 1～ 6月期间由于使用头孢菌素导致的双硫仑样反应 40例进行回顾性分析。结果 :①双硫仑样反应可出现于各性别、年龄及原发病的患者。②导致双硫仑样反应的药物见于头孢唑啉、头孢哌酮、头孢哌酮加舒巴坦、拉氧头孢等。③症状有颜面潮红、胸闷、头痛、心悸、恶心呕吐、气促、烦躁、低血压、心绞痛、呼吸困难等。④接触含乙醇制品的途径除饮用各种酒类外还见于反复乙醇皮肤消毒及服用藿香正气水等含乙醇制剂。⑤双硫仑样反应出现于使用头孢菌素的过程中及疗程结束后 72h内。⑥双硫仑样反应出现于饮酒后 10～ 40min。⑦一般于 3 0min～ 12h内缓解。结论 :医护人员应对双硫仑样反应给与足够的重视 ,尤其是老年人和心血管疾病患者。
Objective:Make clinical physicians pay great attention to disulfiram-like reactions caused by cephalosporin. Method:Backward-analyze 40 disulfiram-like reactions caused by cephalosporin between January to June of 2003 in union hospital. Results:① Disulfiram-like reactions can be seen in different sexes, ages, primary diseases. ②Disulfiram-like reaction can be caused by cephazolin, cefoperazone, cefoperazone and sulbactam, latamoxef and so on. ③Symptoms are flush, chest distress, headache, palpitation, nausea, vomit, shortbreath, dysphoria, hypotension, angina, dyspnea and so on. ④Besides drink all kinds of wines, repeating skin disinfect by ethanol or take preparations containing ethanol such as huoxiang zhengqishui can also cause disulfiram-like reactions. ⑤Disulfiram-like reaction appears when cephalosporin was being used or within 72 hours after cephalosporin had been used. ⑥Disfiram-like reaction appears 10-40 minutes after drink. ⑦Disulfiram-like reactions are normally be relieved in 12 hours after treatment. Conclusion:Physicians and nurses should pay great attention to disulfiram-like reactions caused by cephalosporin, especially to the old and those patient with cardiovascular diseases.
出处
《医药导报》
CAS
2004年第1期61-62,共2页
Herald of Medicine
关键词
头孢菌素
双硫仑样反应
Cephalosporin
Disulfiram-like reaction
