摘要
目的 研究系统性红斑狼疮 (SLE)并发重症血小板减少的临床特征 ,并与慢性特发性血小板减少性紫癜 (CITP)急性发作进行对比。方法 比较SLE并发重症血小板减少组 (SLE组 )和CITP组病人的出血情况、血小板相关抗体、骨髓巨核细胞成熟障碍程度、对泼尼松(≥ 1mg·kg-1·d-1)联合长春新碱近期治疗效果等的差异。结果 SLE组出血程度轻 ,以皮肤、黏膜出血为主 ,而CITP组出血程度重 ,以黏膜和脏器出血为主 ;两组间血小板相关抗体差异无显著性 (P>0 0 5 ) ;SLE组骨髓巨核细胞总数显著低于CITP组 (P <0 0 5 ) ,巨核细胞成熟被阻碍在颗粒巨核细胞阶段的程度低于CITP组 ;SLE组泼尼松 (≥ 1mg·kg-1·d-1)联合长春新碱的近期疗效明显低于CITP组 (P <0 0 5 )。结论 SLE并发重症血小板减少在骨髓巨核细胞成熟障碍的程度。
Objective To study the clinical characteristics of systemic lupus erythematosus (SLE) associated with severe immune thrombocytopenia.Methods Data from 30 SLE patients associated with severe immune thrombocytopenia and 26 patients with chronic idiopathic thrombocytopenic purpura (CITP) were collected and analysed.The difference in bleeding,platelet-associated immune globulin G (PAIgG),total number of bone marrow megakaryocytes,block phase of megakaryocyte differentiation,and response to the prednisone (≥1 mg·kg -1·d -1) and vincristine were compared between SLE group and CITP group.Results The slight bleeding (petechial and mucocutaneous was) mainly seen in SLE group,however the severe bleeding such as intracranial and gastrointestinal tract bleeding was mainly seen in CITP group.The number of bone marrow megakaryocytes were lower in SLE group than those in CITP group (P<0.05).The block phase of megakaryocyte differentiation occurred at the phase of granular-megakaryocyte in both groups,however,the block phase seemed to mainly occur at the phase of hemopoietic cells in SLE group.Response to prednisone and vincristine was poorer in SLE group than in CITP group (P<0.05).There was no difference in the titer of PAIgG between SLE and CITP groups (P>0.05).Conclusion Even though some similarities are seen in both SLE and CITP groups,SLE patients with severe immune thrombocytopenia have their own clinical characteristics.
出处
《中华风湿病学杂志》
CAS
CSCD
2003年第12期749-751,共3页
Chinese Journal of Rheumatology
关键词
系统性红斑狼疮
重症血小板减少
临床特征
合并症
Lupus erythematosus,systemic
Purpura,thrombocytopenic,idiopathic
Thrombocytopenia
