摘要
目的 确定母鼠妊娠后期慢性束缚应激对其子代学习记忆行为的影响。方法 于母鼠怀孕 13～ 2 0d ,每天进行3次束缚应激 ,每次 4 5min。分别于雌、雄仔鼠 1月龄和 3月龄时进行Morris水迷宫行为学测试 ,分析产前经历束缚应激对子代大鼠空间学习记忆能力的影响。结果 1月龄和 3月龄产前应激子代寻找平台的潜伏期较对照组均明显延长 (P <0 .0 5 ) ,1月龄子代在直线式和随机式的搜索策略上亦存在差异 (P <0 .0 5或P <0 .0 1)。结论 产前应激可损伤子代的空间学习记忆功能 。
Objective To determine the effect of chronic restraint stress during the late pregnancy on the behavior parameters of learning and memory of the rat offspring. Methods Stress was inflicted each day of pregnancy from day 13 to day 20. Pregnant females were individually restrained for 45 min three times a day. After delivery, one-month-old and three-month-old female and male rats were examined in Morris water maze to analyze the effect of exposure to prenatal restraint stress on the spatial learning and memory. Results In comparison to the control group, the latency to find the platform in the prenatally stressed group was significantly prolonged in both one-month-old and three-month-old offsprings (P<0.05). There was also a difference in the search strategy of straight and random patterns in one-month-old offsprings (P<0.05 or P<0.01). Conclusion Prenatal stress has a long-time impairment on the function of spatial learning and memory of the offspring.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2003年第6期572-574,共3页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
西安交通大学重点培植项目
