摘要
目的：评价放射性核素五价锝标记的二巯基丁二酸[^(99m)TC（V)-DMSA]则显像对甲状腺髓样癌（MTC）的临床价值。方法：43例各种甲状腺肿瘤术前患者、12例MTC术后拟进一步治疗的患者和8例MTC根治术后患者接受了1～3次^(99m)Tc（V）-DMSA显像研究。结果：^(99m)Tc（V）-DMSA能被MTC高度摄取，图像清晰，正常甲状腺组织及其它甲状腺良恶性肿瘤不摄取放射性，^(99m)Tc（V）-DMSA对MTC诊断灵敏度为81.8％（18/22），特异性为100%（41/41）,准确性为93.7％（59/63）。^(99m)Tc（V)-DMSA能特异性寻找术后残留或复发、转移灶，能发现小至1cm、B超和CT不易识别、临床难于扪及的MTC病灶，与血降钙素水平一起检测，可望早期发现亚临床病灶。结论：^(99m)Tc（V）-DMSA显像是MTC的一个特异性检查手段，对于MTC的诊断、定位、监测疗效和随访有重要的临床价值。
Background／Aims:To evaluate the clinical value of ^(99m)Tc(V)-DMSA scintigraphy for medullary carcinoma of the thyroid(MTC). Methods:43 patients with malignant or benignepisodes of thyroid before operation,12 MTC patients who would receive further therapy and 8 followed-up with serum calcitonin level detection were examinated with^(99m)Tc(V)-DMSA imaging at l～3 times.Results:The results show that^(99m)Tc（V)-DMSA were highly uptaked bythe lesions of MTC and its sensitivity,specificity and accuracy for MTC were 81.8％(18／22),100％(41／41)and 93.75％(59／63)respectively.Conclusion:^(99m)Tc(V)-DMSA scintigraphy seems tobe a important and specific examination for the diagnosis,locating and following-up of the MTC.
出处
《外科》
1997年第1期10-12,共3页
