摘要
目的 :观察降钙素基因相关肽 (CGRP)在成年豚鼠耳蜗中的分布。方法 :采用免疫组织化学 ,光镜观察的方法 ,对CGRP在豚鼠耳蜗中的分布进行研究。结果 :CGRP阳性反应物分布于螺旋神经元 ,骨螺旋板神经孔 ,内毛细胞、外毛细胞与外支持细胞交界区 ,螺旋韧带血管纹。结论 :CGRP广泛分布于豚鼠耳蜗 ,是耳蜗传出神经系统重要的神经递质或神经调质 ,CGRP可能通过调节螺旋神经元、毛细胞和支持细胞等影响听功能 。
Objective:To observe the distribution of CGRP in guinea pig cochlea. Method:CGRP was labeled by immunostaning technique. Distribution of CGRP immunoreactivity was observed with light microscopy.Result:CGRP immunoreactivity was located in SGN, nerve fibers at osseous spiral lamina, stria vascularis, IHC, adjacent area of OHC and Deiters' cells.Conclusion:CGRP distributes extensively in guinea pig cochlea. CGRP may play an important role as neurotransmitter and/or neuromodulator to hearing function by modulating HC, supporting cells, SGN and other neurons along the process of auditory nerve.It may have effect on on cochlear blood flow,too.
出处
《临床耳鼻咽喉科杂志》
CAS
CSCD
北大核心
2004年第1期41-42,共2页
Journal of Clinical Otorhinolaryngology
关键词
降钙素基因相关肽
耳蜗
豚鼠
Calcitonin gene related peptide
Cochlea
Guineapigs
