摘要
目的 观察五酯胶囊对抗结核药物所致肝损害的防治效果。方法 初治肺结核 1 79例 ,给予 2HRZS(E) /4～1 0HR抗结核治疗 ,治疗组 96例 ,全程加服五酯胶囊 ;对照组 83例 ,全程加服葡醛内酯。结果 治疗组出现肝损害 7例 (7.3% ) ,其中HBsAg阳性患者出现肝损害 5例 (1 1 .4 % ) ;对照组出现肝损害 32例(38.6 % ) ,其中HBsAg阳性患者出现肝损害 2 0例 (52 .6% )。两组差异显著 (P <0 .0 1 )。HBsAg、HBeAg阳性患者在抗结核治疗中肝功能更容易受损害。结论 五酯胶囊在防治抗结核药物所致肝损害的发生是有效的 。
Objective To determine the effect of Wu-Zhi Cap su les in preventing and treating liver damage caused by anti-tuberculosis drugs.Methods 179 initially-treated pulmonary tuberculosis patients who received the regimen of 2HRZS(E)/4～10HR were randomly separated into 2 grou ps:Observe group,96 cases,supplemented with Wu-Zhi Capsules for six mouths and Control group,83 cases,received glucurolactone.Results There were 7 cases who had liver damage in observe grou p (7.3%),5 cases with HBsAg positive (11.4%);There were 32 cases who had liver damage in control group (38.6%),20 cases with HBsAg positive (52.6%).There wa s signific ant difference between the 2 groups (P<0.01).HBsAg,HBeAg positive patients were more likely to have liver damage in anti-tuberculosis treatment.Conclusion Wu-Zhi capsules is effective in preventing and trea ting liver damage caused by anti-tuberculosis drugs,HBsAg,HBeAg positive patien ts' liver function should be monitored in the early period of anti-tuberculosis treatment.
出处
《中国防痨杂志》
CAS
北大核心
2003年第6期371-373,共3页
Chinese Journal of Antituberculosis
