摘要
合成药NO - 1886是脂蛋白脂肪酶 (LPL)的激动剂 ,能降低血浆甘油三酯 (TG)并升高高密度脂蛋白胆固醇 (HDL -c)水平。我们曾发现NO - 1886还具有降低血糖的作用。本研究主要观察NO - 1886对糖尿病兔胰岛素抵抗及 β -细胞功能方面的影响。用高糖高脂饲料诱导 ,使新西兰兔血浆葡萄糖升高 ,发生胰岛素抵抗。在高糖高脂饲料中添加 1%NO - 1886进行治疗。结果发现NO - 1886可抑制血清葡萄糖升高 ,经糖耐量和胰岛素敏感性试验检测 ,NO - 1886可保护胰岛素的急性相分泌 ,增强胰岛素对葡萄糖的清除能力。研究结果提示NO - 1886具有改善胰岛素抵抗、降低血糖的作用。
Synthetic compound NO-1886 is a lipoprotein lipase activator which lowers plasma triglycerides and elevates high-density lipoprotein cholesterol(HDL-C). Recently, we found that NO-1886 also had an action of reducing plasma glucose in high fat/high sucrose diet induced diabetic rabbit. In the current study, we investigated the effects of NO-1886 on insulin resistance and B-cell function in the rabbits. Our results showed that high fat/high sucrose feeding increased plasma glucose levels . This diet also induced insulin resistance, impairment of acute insulin response to glucose loading. Supplementing 1% NO-1886 into the high fat/high sucrose diet resulted in decreased serum glucose levels. We also found a clear increased glucose clearance and a protected acute insulin response to intravenous glucose load by NO-1886 supplementation. These data suggest that NO-1886 suppresses the elevation of blood glucose in rabbits induced by feeding a high fat/high sucrose diet probably through improving insulin resistance.
出处
《中国现代医学杂志》
CAS
CSCD
2003年第22期37-41,共5页
China Journal of Modern Medicine
关键词
NO-1886
新西兰兔
胰岛素抵抗
糖尿病
NO-1886
CAS 133208-93-2
Glucose
Triglycerides
Free fatty acids
Insulin resistance
Diabetes
Rabbits
