摘要
目的 探讨肾癌组织中血管内皮生长因子的表达及其与肾癌生物学行为的关系。方法 应用单克隆鼠抗-VEGF抗体通过免疫组化SP法研究肾癌中血管内皮生长因子的表达。结果 60例肾癌组织中35例(58.3％)血管内皮生长因子阳性。血表达与组织学分级(P<0.05)和TNM分期(P<0.05)均明显相关。 结论 血管内皮生长因子表达对肾癌生物学行为有重要影响,设法抑制血管内皮生长因子有望成为肾癌治疗的另一有效方法。
AIM To investigate the expression of vascular endothelial growth factor (VEGF) in renal cell carcinoma (RCC)and the relationship between VEGF and biological behavior of RCC. METHODS Immunohistochemical analysis of VEGF was performed by applying the streptavidin peroxidase(SP) conjugated method. RESULTS Thirty-five tumors (58.5%) were classified as VEGF positive. A significant correlation was found between VEGF expression and both the nuclear grade (P<0.05) and the TNM stage (P<0.05). CONCLUSION Expression of VEGF has an important influence on the biological behavior of RCC. Its inhibition might be further used in the treatment of RCC.
出处
《现代泌尿外科杂志》
CAS
2003年第4期219-221,共3页
Journal of Modern Urology
