摘要
目的 探讨超液化碘油与抗肿瘤药物相混合行肝动脉栓塞化疗治疗不能手术切除及内科静脉化疗不佳的中晚期肝癌的方法和疗效。方法 经股动脉行Seldinger法插管肝动脉超选治疗96例,单次剂量为:丝裂霉素10mg,顺铂60mg,吡柔比星60mg,5-Fu 1500mg,法国产超液化碘油10～20ml。结果 原发性肝癌:治疗前82例甲胎蛋白都有不同程度升高,其高低范围为626～2565ng/ml,通过治疗后数值明显下降,范围在35ng/ml以下并可达到正常水平;转移性肝癌:治疗前甲胎蛋白虽无明显升高,但通过治疗后可显著改善临床症状。二者用CT或术中DSA造影对照,均见病灶明显缩小。82例原发性肝癌中有6例治疗后病灶已全部消失。96例患者生活质量得到提高,生存期延长。结论 对Child B,C级中晚期肝癌患者,抗肿瘤药物吡柔比星与碘油混合乳剂行肝动脉栓塞治疗,绝大多数患者都能耐受,且能控制肿瘤的发展,并有缩小肿瘤的疗效。
Objective To investigate the clinical efficacy and methods of intrahepatic artery chemoemboli-zation with ultra fluid lipoid combined with anticarcinoma drugs in treatment of middle-late stage hepatic carcinoma which can not be operated and treated with intravenous chemotherapy. Methods Supper-selective hepatic artery Seldinger catheterization via formal artery was performed in 96 cases. Single dose was mitomycin(MMC) 10 mg,cis-platin(CDDP) 60 mg,pirarubicin(THP) 60 mg, 5-Fu 1 500 mg and ultra fluid lipoid made in France 10-20 mg. Results In the group of 82 patients with primary hepatic carcinoma, the level of AFP increased to different degrees. Ranging from 626ng/ml to 2 565 ng/ml before treatment. After treatment the level of AFP declined obviously, usually to below 35 ng/ml and reaching the normal level. In the group of metastatic hepatic carcinoma, the level of AFP heightened slightly before treatment, and the symptoms possibly improved obviously after treatment. Examined with CT scan and DSA arteriography during the operation, the focus was found reduced in size. Of the 82 primary hepatic carcinoma patients, 6 were cured.The quality of life of 96 patients improved and their life span was prolonged . Conclusion Hepatic artery embolization with lipoidal emulsion combined with anticarcinoma drug for treatment of Child grades B and C hepatic carcinoma patients, which can be accepted by most patients, can not only control the development of the tumor, but also reduce its size.
出处
《中国肿瘤临床与康复》
2003年第5期424-426,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
