摘要
目的 了解GST-π在胃癌中的表达及其与胃癌生物学行为的关系。方法 应用免疫组化法检测85例行根治性切除的胃癌组织中GST-π的表达情况。结果 GST-π在胃癌组织中的阳性表达率为71.8％。其阳性表达与肿瘤的浸润深度及淋巴结转移个数有关,与大体类型及生长方式无关,与病理组织分型无关。在临床分期中,Ⅰ、Ⅱ、Ⅲ期与Ⅳ期比较差异有显著性。结论 通过监测GST-π在胃癌组织中的表达可以起到预测预后的作用,同时对了解耐药程度、选择合理的化疗药物、实行个体化治疗及进行耐药逆转治疗具有十分重要的意义。
Objective To investigate the expression of glutathione S-transferase(GST)-π in gastric carcinomas and its relationship with the biological behaviour of gastric carcinomas. Methods Eighty-five human gastric carcinoma samples were studied for the expression of GST-π by means of immunohistochemistry. Results The expression of GST-π was 71.8% in gastric carcinoma tissues. There is no significant relationship between the expression levels and Borrmann types, growth style and histological types.There were significant relationships between the depth of tumor invasion, the number of lymph nodes involved and the high expression of GST-π. The expression was higher in stage IV than in stages I , II and III . Conclusion GST-π is useful tumor marker for predicting prognosis and drug resistance and selecting chemotherapy drug.
出处
《中国肿瘤临床与康复》
2003年第5期415-416,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
