摘要
研究了毛冬青甲素体外给药对花生四烯酸诱导兔血小板聚集和聚集液中过氧化脂质含量变化的影响。结果表明,毛冬青甲素在较大样本中可抑制花生四烯酸诱导的血小板聚集和过氧化脂质的生成,两者间具有一定的相关性,表明毛冬青甲素抗血小板作用可能与抑制过氧化脂质有关。由于后者的生成量与花生四烯酸代谢活性产物TxA_2的生成有近似等摩尔增加的关系,故推测毛冬青甲素对TXA_2的合成有阻断作用,这种作用可能为毛冬青甲素抗血小板功能的作用机制。
This paper reported the effect of ilexonine A (IA) administration in vitro on rabbit platelet aggregation induced by arachidonic acid (AA) in vitro, and the change of malon- dialdehyde (MDA)level in aggregated platelet suspension. The results showed that IA could inhibit platelet aggregation and MDA formation induced by AA. A certain correlation was shown, Between inhibiting rate of aggregation and decrease of MDA level, suggesting the antiplatelet effect of IA might be related to its inhibiton of the formation of MDA. According to MDA is the parameter of thromboxane A_2 (TXA_2) synthesis (TXA_2 is an active metabo- lite of AA during platelet activation), we hypothesiz that IA might interfere with the TXA_2, formation and it may be the mechanism of the antiplatelet effect of ilexonine A.
