摘要
探讨肾主骨理论与肾脏 1α羟化酶关系。 6月龄健康雄性SD大鼠 4 0只 ,随机均分为对照组、模型组、中药组、西药组 4组。肾脏局部辐射制备骨质疏松症模型 ,照射后 1周开始用药 ,中药组灌胃给予中药 (菟丝子、何首乌等提取的活性部位 ) 1 34g·kg- 1·d- 1,西药组给予萌格旺 0 1μg·kg- 1·d- 1,其他两组以等容量 0 .5 %CMC替代。 3个月后 ,分别测定各组大鼠腰椎、股骨骨密度、骨生物力学指标以及肾脏羟化酶活性。结果 :与对照组比较 ,模型组骨密度、骨生物力学指标以及羟化酶活性均降低 ;与模型组比较 ,中药组骨密度、骨生物力学指标以及羟化酶活性均显著改善。提示补肾中药能提高放射损伤大鼠肾脏 1α羟化酶的活性 ,这可能是“肾主骨”理论的重要生理学基础之一。
To explore the relationship between kidney nourishment and renal 1-α-hydroxylase,40 male SD rats were randomized into four groups. All rats were made to be of osteoporosis by local radiation. After one-week radiation,herbal group was given kidney-nourishing herbs (1.34g· kg -1 · d -1 ),western medicine group was given menggewang (0.1μg· kg -1 · d -1 ),the other two groups were given equal amount of normal saline. Three months later,the bone density of lumbar vertebrae and femur,bone biomechanics and renal 1-α-hydroxylase were detected. Results: Compared with control group,the bone density,bone biomechanics and renal 1-α-hydroxylase reduced in model group; compared with model group,the bone density,bone biomechanics and renal 1-α-hydroxylase reduced in herbal group increased. It is indicated that kidney-nourishing herbs can increase the activity of renal 1-α-hydroxylase in rats after radiation,this may be one of the mechanisms of kidney controlling bones.
出处
《上海中医药杂志》
北大核心
2003年第12期42-44,共3页
Shanghai Journal of Traditional Chinese Medicine
