摘要
目的 :研究猫左侧扣带回前部内脏伤害与非伤害感受神经元的自发生物电活动 ,从神经元水平进一步了解大脑皮质内脏伤害感受的特性及机制。方法 :以电刺激内脏大神经作为内脏痛的实验动物模型 ,应用在体玻璃微电极细胞内电位记录技术。结果 :根据神经元对电刺激内脏大神经产生诱发反应的特性 ,将其分为内脏伤害感受神经元 ( 89.13% )和内脏非伤害感受神经元 ( 10 .87% )。两种神经元的自发生物电活动形式、自发放电频率和幅值、以及两者的静息电位无明显差异。但是 ,有自发放电活动的内脏感受伤害神经元的例数明显高于内脏非伤害感受神经元中有自发放电活动的神经元的例数。结论 :左侧扣带回前部存有内脏伤害感受神经元和内脏非伤害感受神经元 。
Objective: Our aim was to study the spontaneous biological electric activities of visceral nociceptive and non nociceptive neurons in left anterior cingulate gyrus of cats.Methods:Electrically stimulating greater splanchnic nerve (GSN) was used as an experimental model of visceral pain. The intracellular recording technique of glass microelectrode in vivo was used. Results:According to characteristics of the evoked response to stimulating GSN, the neurons in the left anterior cingulate gyrus (ACG) could be classified into visceral nociceptive neurons (VNNs, 89.13%) and non visceral nociceptive neurons(NVNNs, 10.87%). Modes, frequencies, and amplitudes of spontaneous biological electric activities of VNNs and NVNNs were not obviously different. The resting membrane potential of the both were not obviously different. However, the percentage of spontaneous firing neurons in VNNs was significantly higher than that in NVNNs.Conclusion:There are VNNs and NVNNs in the left ACG. The excitability of the former was higher than that of the latter.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2003年第6期498-499,502,共3页
Journal of China Medical University
关键词
扣带回前部
内脏痛
伤害感受神经元
细胞内电位
自发生物电活动
anterior cingulate gyrus
visceral pain
nociceptive neuron
intracellular recording
spontaneous biological electric activity
