摘要
目的 评价脑钠素 (BNP)测定对充血性心力衰竭 (心衰 ,CHF)诊断的价值。方法 呼吸困难住院患者 85例 ,根据病因分为心衰组和非心衰组 ,采用ELISA法测定两组血浆BNP水平。结果 心衰组血浆BNP浓度 [( 65 4.1± 3 0 2 .6)ng/L]显著高于非心衰组 [( 2 0 6.3± 5 3 .7)ng/L] ,两组比较差异有非常显著性 (P <0 .0 0 1) ;以正常对照组的血浆BNP浓度的 ( x±s1.96s)为标准 ,诊断CHF的敏感性为 96% ,特异性为 93 %。结论 血浆BNP是诊断CHF较好的血液指标 。
Objective To evaluate diagnostic value of plasma brain natriuretic peptide(BNP) in patients with congestive heart failure(CHF).Methods 85 patients with acute dyspnea and whose B-type natriuretic peptide was measured with ELISA assay.The clinical diagnosis of congestive heart failure was adjudicated by two independent cardiologists,who were blinded to the results of the B-type natriuretic peptide assay.Thirty patients with normal ventricular function served as control group.Results The plasma BNP concentrations of CHF were significantly higher than that of non-CHF(P<0.001 respectively),A plasma BNP concentration exceeding mean of the controls(x+1.96s) had a sensitivity of 96% and a specificity of 93% for diagnosis of congestive heart failure in patients with acute dyspnea.Conclusions Used in conjunction with other clinical information, measurement of B-type natriuretic peptide is useful in establishing or excluding the diagnosis of congestive heart failure in patients with acute dyspnea.
出处
《临床内科杂志》
CAS
北大核心
2003年第12期642-643,共2页
Journal of Clinical Internal Medicine
关键词
心力衰竭/诊断
脑钠素
Congestive heart failure/diagnosis
Brain natriuretic peptide
