摘要
目的 探讨过氧化物酶体增殖体激活受体γ2 (peroxisomeproliferationactivatedrecep tor γ2 ,PPAR -γ2 )基因外显子B的Pro12Ala多态性与 2型糖尿病血脂的关系。方法 用聚合酶链反应 -限制性片段长度多态性分析方法 ,检测 2 0 2名 2型糖尿病的PPAR γ2基因型及相关临床指标。结果 PPAR γ2基因在 2型糖尿病中存在Pro12Ala变异 ,以PP型为主。 2型糖尿病中 ,PPAR γ2基因Pro12Ala多态性与体重指数 (BMI) ,血糖 ,血脂 ,空腹胰岛素 ,胰岛素抵抗 ,血压均无明显相关性。在BMI≥ 2 5的肥胖 2型糖尿病人群中 ,携带A等位基因者的TG(甘油三酯 )和HDL C(高密度脂蛋白胆固醇 )分别明显高于和低于携带P等位基因者 ,在非肥胖组中没有此差别。结论 在肥胖状态下 ,Pro12Ala多态性能加重 2型糖尿病的脂质紊乱 。
Obejctive To investigate the association of Pro12Ala variant in peroxisome proliferation activated receptor-γ2 gene with T2DM combined with hyperlipidemia.Methods The genotypes of Pro12Ala variant in PPAR-γ2 gene were determined by polymerase chain reaction-restriction fragment length polymorphisms assay in 202 subjects who were diagnosed T2DM.The clinical data were also analyzed.Results there is variant of PPAR-γ2 gene in T2DM.The majority genotype is PP.The Pro12Ala variant of PPAR-γ2 was not significantly associated with BMI,fasting glucose,lipid,fasting insulin,insulin resistance,blood pressure in T2DM.In the group of the obese T2DM which BMI is over 25,triglyceride of the subjects which the allele is A is higher significantly than that the subjects which allele is P.High dense lipoprotein of the subjects which the allele is A is lower significantly than that the subjects which allele is P.The control group has no the difference.Conclusion The above data showed that the variant of PPAR-γ2 could promote the development of hyperlipidemia in obesity T2DM and especially play a genetic role in obesity state.
出处
《临床内科杂志》
CAS
北大核心
2003年第12期631-633,共3页
Journal of Clinical Internal Medicine
