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β-防御素及其在皮肤系统的研究进展

Study Progress of β-defensins and Its Application for Skin Diseases
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摘要 阐述了国外 β -防御素 (HBD)的分布分类、表达调控、生物学活性及在具体皮肤病中的研究情况和皮肤病领域的应用前景 ,认为这必将为治疗皮肤病开辟更新更广阔的道路 ,同时也可以为探讨中医的“卫气学说” The author expounded the distribution, classification, expression, adjustment, biological activity, and point out the application of it and relative study on some skin diseases. He considered that it will provide new way for the treatment of skin diseases and the study of Defensive-qi.
作者 张志勇 曾昭武 杨志波
机构地区 湖南中医学院第二附属医院
出处 《湖南中医药导报》 2003年第11期54-55,共2页 Hunan Guiding Journal of Traditional Chinese Medicine and Pharmacology
关键词 Β-防御素 皮肤 研究进展 β-defensins Skin Study progress
分类号 R275.9 [医药卫生—中西医结合]
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参考文献9

  • 1Ali RS, Falconer A, Ikram Met al. Expression of the peptide antibiotics human beta defensin - 1 and human beta de-fensin- 2 in normal human skin. J Invest Dermatol. 2001 Jul;117(1) :106 - 111.
  • 2Frye M , Bargon J, Gropp R, Expression of human beta - de-fensin - 1 promotes differentiation of keratinocytes. J Mol Med 2001 Jun ;79(5 - 6) :275 - 282.
  • 3Duits LA, Rademaker M, Ravensbergen B et al. Inhibition of hBD - 3, but not hBD - 1 and hBD - 2, mRNA expression by corticosteroids. Biochem Biophys Res Commun.2001 Jan 19;280(2) :522 -525.
  • 4Dinulos JG, Mentele L, Frederieks LP et al Keratinocyte expression of human beta defensin 2 following bacterial infection: role in cutaneous host defense. Clin Diagn Lab Immunol. 2003 Jan: 10( 1 ) : 161 - 166.
  • 5Befus AD, Mowat C, Gilchrist Met al. Neutrophil defensins induce histamine secretion from mast cells: mechanisms of action. J Immunol. 1999 Jul 15 ;163(2) :947 -953.
  • 6Mizukawa N, Sugiyama K, Yamachika E et al. Presence of defensin in epithelial Langerhans cells adjacent to oral carcinomas and precancerous lesions. Anticancer Res. 1999 Jul-Aug; 19(4B) :2969 - 2971.
  • 7Chronnell CM, Ghali LR,Mi RS et al. Human beta defensin- 1 and - 2 expression in human pilosebaceous units : upreg-ulation in acne vulgaris lesions. J Invest Dermatol 2001 Nov;l17(5) :1120 - 1125.
  • 8Huh WK,Oono T ,Shirafuji Yet al . Dynamic alteration of human beta -defensin 2 localization from cytoplasm to inter-cellular space in psoriatic skin. J Mol Med 2002 Oct; 80(10) :678 -684.
  • 9Ong PY ,Ohtake T,Brandt C et al . Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 2002 Oct 10 ;347 ( 15 ) : 1151 - 1160.
湖南中医药导报
2003年 第11期

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