摘要
目的 研究小檗碱对实验大鼠血脂和组织内甘油三酯沉积的影响。方法 设计七组大鼠:普食对照组,普食小檗碱治疗组;高脂对照组,高脂小檗碱治疗组;高脂饮食与极小剂量链脲霉素诱导的糖尿病对照组,糖尿病小檗碱治疗组和糖尿病二甲双弧治疗组。5周后观察分析各组血清甘油三酯(TG)、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、游离脂肪酸(FFA)水平以及肝脏和骨骼肌中甘油三酯含量。结果 小檗碱使普食、高脂、糖尿病鼠的血FFA水平分别下调14％、24％、20％,TG分别降低11％、57％、14％。小檗碱使高脂鼠肝脏和骨骼肌中的甘油二酯含量分别减少36％和23％。结论 小檗碱对实验大鼠的脂代谢有显著的改善作用,该药能降低血清和组织中的甘油三酯含量,同时降低血清FAA水平。
Objective To study the effects of berberine on blood lipid and tissue triglyceride contents in experimental rats. Methods Seven groups of rats were obtained: untreated common fed, berberine - treated common fed, untreated high - fat fed, berberine - treated high - fat fed; untreated diabetes , berberine - treated diabetes and metformin - treated diabetes rats. Serum triglyceride, total cholesterol , high density lipoprotein - cholesterol, low density lipoprotein - cholesterol, free fatty acid ( FFA ) , hepatic and muscle triglyceride contents were detected. Results Serum FFAs of common fed, high - fat fed and diabetic rats were down - regulated by 14% , 24% and 20% with berberine, respectively. And serum triglyceride of these three groups was also decreased by 11% , 57% and 14% , respectively. Hepatic and muscle triglyceride contents of high - fat fed rats were decreased by 36% and 23% with berberine. Conclusion Lipid metabolism of experimental rats was improved significantly by berberine. Berberine is able to decrease the triglyceride concentrations of serum or tissue and the levels of FFA.
出处
《上海第二医科大学学报》
CSCD
2003年第B10期28-30,共3页
Acta Universitatis Medicinalis Secondae Shanghai
