摘要
目的 :研究转化生长因子β1 (TGF-β1 )、P2 1WAF 1 /CIP1 在非小细胞肺癌中的表达以探讨肿瘤对 TGF-β信号通路负调控的逃逸机制。方法 :对非小细胞肺癌 6 0例标本组织及 15例正常肺组织中 TGF-β1 、P2 1WAF 1 /CIP1 蛋白表达进行免疫组化研究。结果 :TGF-β1 、P2 1WAF1 /CIP1在肿瘤组织中均高表达 ,且 TGF-β1 与淋巴结转移、肿瘤浸润程度、TNM分期等临床病理因素有关。结论 :TGF-β1 在肺癌中可作为一个较好的预后因子 ,TGF-β1 、 P2 1WAF 1 /CIP1 的表达一定程度上均能反映肿瘤的生物学行为。
Objective:To investigate the relationships between expression tramsforming growth factor-β 1(TGF-β 1)、P21 WAF1/CIP1 and clinicophathology in non-small cell lung carcinoma(NSCLC),to explore the mechanism by which Lung cell escape the TGF-β signaling pathway mediated negative control.Methods:SP immunohistochemistry performed in all case.Results:TGF-β 1、P21 WAF1/CIP1 were over expressed in NSCLC.The over-expression of TGF-β 1 was correlated with lymph node metastasis、invasion and clinical stages but has no relationship with the other clinicopathologic features,including age, gender ,histology, and tumor grade.Conclusion:TGF-β 1 may be an independent prognosis factor. Expression of both TGF-β 1 and P21 WAF1/CIP1 may be a predictor tumor to biological behavior.
出处
《南通医学院学报》
2003年第4期414-414,416,共2页
ACTA Academiae Medicinae Nantong
