摘要
目的 :探讨肝局灶结节性增生 (FNH)的病理形态及免疫组化特征。方法 :采用 HE和免疫组化染色对 16例肝 FNH进行病理学观察。结果 :FNH病理特征为孤立的、中央有纤维瘢痕的结节性肿块 ,纤维瘢痕中可见厚壁血管及增生的小胆管。结节间增生的小胆管与结节周边肝细胞相移行 ,且两者角蛋白表达相似。结论 :FNH是一瘤样病变 ,其中增生的小胆管可能来自结节内肝细胞化生 ,应与肝细胞腺瘤、肝细胞肝癌 (尤其纤维板层型肝癌 )及结节状再生性增生进行鉴别。
Objective:To study the pathological morphology and immunohistochemical features of hepatic focal nodular hyperplasia (FNH).Methods:Sixteen cases of FNH were studied with HE staining and immunohistochemistry.Results:The pathological features were a solitary and nodular mass with central fibrous scar that contained thick-walled vessels and proliferated bile ducts.Internodular bile ducts proliferation is abundant and merge imperceptibly with hepatocytes near the fibrous septa. Immunohistochemically, the Keratin expressed by hepatocytes and by the proliferated bile ducts were similar.Conclusion: FNH is a tumor-like lesion , in which the proliferated bile ducts probably arised from hepatocellular metaplasia in the nodules.It should be differentiated from hepatocellular hepatocellular adenoma,(fibrolamellar hepatocellular carcinoma in particular)and nodular regenerative hyperplasia of the liver.
出处
《南通医学院学报》
2003年第4期383-384,共2页
ACTA Academiae Medicinae Nantong
