摘要
目的探讨乌司他丁对小儿手术后的保护作用。方法利用粒细胞弹性蛋白酶和纤维连接蛋白作为指标对手术患儿进行随机的分组研究。结果粒细胞弹性蛋白酶的血清浓度在小儿手术后明显升高,在术后当天为最高峰,以后逐渐下降,乌司他丁组下降的速度明显快于对照组,在术后第3d即有显著的差异性,差异性持续到术后第7d。血清纤维连接蛋白浓度的恢复在乌司他丁组明显快于对照组,在术后第7d即有显著的差异,对照组血清纤维连接蛋白浓度在术后第14d仍未能达到乌司他丁组的水平。结论乌司他丁对小儿手术后的再创伤有保护作用,同时能促进机体的恢复,是一种能使小儿平稳度过围手术期的有效药品。
Objective To explore the protective effects of ulistatin on the young children after significant operation.Methods We used elastase and fibronectin of granulocytes as markers,the children who underwent significant operation were divided into ulistatin treated group and control group,and efficacy of the ulistatin was studied.Results Serum elastase activity and concentraction of fibronectin in the granulocytes were obviously elevated in children at the day after significant operation and reached best high determinative values.Afterwords,these markers level was gradually decline,as compared with control group,decreased velocity in the ulistatin group was remarkable quickened,there was significantly difference between the two group at3rd in postoperation and the high value was persistent existed until at7th days.Recorvery of serum fibronectin concentration in ulistatin treated group was significantly rapid than that in the control group,there was dramatic difference at7th days after signifnicant operation,but serum fibronectin level in control group did no reach the level of ulistatin treated group at14th days..Conclusions Ulistatin treatment could prevent the re-trauma of significant operation.Simultaneously,it also can promot recovery of organism for the sick young children after significante operation.
出处
《临床小儿外科杂志》
CAS
2003年第4期264-265,268,共3页
Journal of Clinical Pediatric Surgery
基金
广东省卫生厅医学科学技术科研立项课目
课题编号:B2001122
