摘要
目的 :探讨高危因素的黄斑drusen与AMD发生的关系。方法 :对视力正常 ,黄斑有drusen的早期AMD患者 3 2例 5 0眼进行了五年的视力 ,眼底检查 ,黄斑光阈值视野检查 ,莹光眼底血管造影随访观察。结果 :在平均随访 60个月后 ,视力由随访前的平均 1 0下降为 0 78,黄斑区 10°内的平均光敏度检查 3 0眼由随访前的 2 8 3±4 5dB下降为 2 5 1dB± 6 1dB ,眼底镜下检查发现黄斑drusen不断增加 18眼 ( 3 6% ) ,不断融合增大 12眼 ( 2 4% ) ,变为软性疣7眼 ( 14 % ) ,地图状萎缩 5眼 ( 10 % ) ,无变化 8眼 ( 16% ) ,眼底荧光血管造影检 3 6眼查发现drusen位于黄斑中心凹外的 2 6眼 ( 72 % ) ,随访中观察到 2 3眼 ( 88% )有快慢不一的发展 ,无明显改变 3眼 ( 12 % ) ,drusen位于黄斑中心凹的 10眼 ( 2 7% ) ,随访中观察到有改变 8眼 ( 80 % )。结论 :对黄斑drusen的动态观察 ,有助于我们对AMD病变发展及演变过程的认识。
Objective:To investigate the relationship between drusens in macula lutea and the development of age-related macular degeneration. Methods:32 cases(50 eyes) of suspiciously early age-related macular degeneration with mormal visual acuity and drusen were involved.the visual acuity,fundus,macular light threshold and fundus fluorescence angiography (FFA) were observed. Results:Average visual acuity declined from 1.0 to 0.78 after mean 60 monthes following-up,and average light threshold of macular 10° declined from 28.3±4.5 dB to 25.1±6.1 dB.The number of drusens in macular lutea increased in 18 eyes (36%),fused and enlarged drusens were found in 12 eyes (24%),soft drusens in 7 eyes (14%),map atrophy in 5 eyes (10%),and no changes in 8 eyes (16%).In 36 eyes with FFA,26 eyes(27%) with drusens outside macular fovea preiously,in which 23 eyes(88%) had some aggravative changes of drusens later,3 eyes (12%) had no obvious changes.And 8 (80%) out of 10 eyes with drusens involved in macular fovea previously had some changes of drusen later. Conclusions:An continuous observation on the changes of drusons in macular lutea would be helpful for people to knowledge the development of age-related macular degeneration.
出处
《中国实用眼科杂志》
CSCD
北大核心
2003年第11期848-850,共3页
Chinese Journal of Practical Ophthalmology
