摘要
本文搜集了《MEDLINE》光盘上1990～1999年所记录的非甾体类抗雄性激素药物氟他胺和比卡鲁胺引起的肝损害病例,及本院发生的肝损害致肝肾衰竭致死病例,介绍了此两药在各国发生肝损害的情况及该国对此采取的措施,详细阐述了其发生肝损害的临床表现、发生机制、防范措施和治疗方法,特别强调了美国FDA以及日本化药公司、美国Sching-Plough公司对上述两药导致肝损害发出的警告。为此建议严重肝功能损害患者禁用氟他胺和比卡鲁胺,对肝功能不全或有肝病史患者应慎用或权衡利弊,其他患者用药过程中应定期监测肝功能,至少每月1次。
Cases with liver damage induced by flutamide and bicalutamide were collected from MEDLINE of 1990-1999 and our hospital. The two drugs' adverse reactions of liver damage happened in some countries and their adoption of appropriate measures are presented in this paper. It is suggested that patients with severe liver damage should not take flutamide and bicalutamide and that individuals with poor liver function or hepatitis history take them cautiously while examined for LFT, once a month at least.
出处
《药物不良反应杂志》
2000年第2期91-94,共4页
Adverse Drug Reactions Journal
