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格列吡嗪控释片治疗老年2型糖尿病临床观察

Clinical effect of controlled-release glipizide in the treatment of aged patients with NIDDM
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摘要 目的 :观察格列吡嗪控释片治疗老年 2型糖尿病的临床疗效。方法 :治疗组 32例老年糖尿病患者服用控释片 ,对照组老年糖尿病患者 2 8例服用速释片 ,两组均测试服药前后空腹血糖、餐后 2小时血糖、胰岛素、糖化血红蛋白、胰岛素样生长因子 - 1 ,并进行组内、组间对比。结果 :控释片及速释片均有较好的降糖效果 ,而控释片可以增加血清胰岛素样生长因子 - 1 ,但不增加血胰岛素。结论 :格列吡嗪控释片对老年 Objective:To investigate the clinical effect of controlled release glipizide in the treatment of aged patients with NIDDM Methods:32 cases aged patients with NIDDM were treated by controlled release glipizide and 28 cases aged patients with NIDDM were treated by immediate release glipizide.Their serum level of FPG, glucose in two hours after dinner,insulin,HbA 1C,IGF 1 were measured and compared before and after treatment Results:Both controlled release glipizide and immediate release glipilide had good effect in lowing the serum level of glucose,controlled release glipizide also increased the serum level of IGF 1 and decreased the serum level of insulin Conclusion: Controlled release glipizied have better effect in the treatment of aged patients with NIDDM
作者 杨彬
出处 《广西医学》 CAS 2003年第12期2406-2408,共3页 Guangxi Medical Journal
关键词 格列吡嗪 控释片 治疗 2型糖尿病 临床观察 老年人 NIDDM Glipizide Aged patients
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参考文献5

  • 1[1]Simonson DC,Kourides IA,Feingolos M,et al. Efficiency,safety, and doesresponse characteristics of glipizide gastrointestinal therapeutic system on glucemic control and insulin in NIDDM results of two multicenter, randomized, plocebo-controlled clinical trial,Diabets Care 1997;20:597
  • 2[3]Berelowitz M, Pischtee C,Cefalu W,et al. Comparative efficacy of a once-daily controlled-release formulation of glipizide and immediaterelease glipizide in patients with NIDDM. Diabetes care 1994 ; 17 :1460
  • 3宁光,赵红燕,骆天红,王笑微,赵列宾,罗邦尧,许曼音,陈家伦.控释格列吡嗪治疗2型糖尿病的效果及安全性[J].中华内分泌代谢杂志,1998,14(3):193-195. 被引量:34
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