摘要
目的 :探讨糖尿病 (DM)作为老年性痴呆 (AD)危险因素的可能机理。方法 :放免法检测 DM组 5 8例 ,正常对照组33人的血浆 β-淀粉样蛋白 (Aβ)、雌二醇 (E2 )水平 ,DM组 2 6例脑 CT扫描。结果 :1 5例脑 CT皮质萎缩 ,脑室扩大。 DM组女性 E2 为 4 .4 6± 4 .31 pg/ml,对照组女性 E2 为 9.4 3± 7.87pg/ml,P<0 .0 1 ,两组有显著差异。DM组 Aβ为 5 8.37± 8.6 5 pg/m l,对照组 Aβ为 6 1 .1 5± 8.39pg/ml,两组无显著差异。结论 :DM作为 AD的危险因素的可能机理 :脑皮质萎缩 ;E2 水平显著降低 ;Aβ被晚期糖基化终末产物 (AGE)
Objective:To study probable mechanism that diabetes mellitus (DM) is risk factor of Alzheimer's disease (AD).Methods:The plasma concentration of β amyloid protein (Aβ) and estradiol (E 2) in group DM (58 cases) and group control (33 subjects) were measured by radioimmunoassay.Brain CT was checked in group DM (26 cases) Results:Brain CT showed cerebrocortex atrophy and ventricles of the brain expanded in 15 cases.E 2 concentration was 4 46±4 31pg/ml in women of group DM, E 2 concentration was 9 43±7 87pg/ml in women of group control( P <0 01),Two groups showed significant difference.Aβ concentration was 58 37±8 65Pg/ml in group DM,Aβ concentration was 61 15±8 39pg/ml in group control,Two groups did not showed significant difference Conclusion:DM is risk factor of AD,The probable mechanism:Cerebrocortex atrophy;E 2 concentration reduce significantly;Aβ becomes to diposited easily after Aβ is modificated with advanced glycation end products(AGE)
出处
《广西医学》
CAS
2003年第12期2386-2387,共2页
Guangxi Medical Journal
