摘要
将6-OHDA 注入大鼠第三脑室,24小时后用电镜细胞化学方法观察下丘脑弓状核内溃变的 CA 能神经元。结果表明:在弓状核内有大量溃变终末,其特征为:轴浆电子密度增高,突触囊泡及线粒体崩解,致密小体形成及多房形溃变图象。大多数溃变终末均不同程度地被胶质细胞突起所围绕。部分弓状核神经元核周质也出现溃变迹象(粗面内质网减少、线粒体变性及致密小体形成等)。溃变的 CA 能神经终末可形成轴树、轴体、轴轴及轴突-伸长细胞突触联系。上述溃变图象符合 DA 能神经的化学损毁表现,故作者认为这些溃变的终末主要属于 DA 能纤维。它们通过多种突触机制调节和影响下丘脑弓状核的功能。弓状核的 DA 能神经支配可能来自下丘脑本身的 A_(12)、A_(14)或 A_(15)细胞群。
6-OHDA was injected into the third cerebroventricle of rats.24 hours later,th
animals were sacrificed and the degeneration of catecholaminergic (CA) nerve term-
inals were studied by electron microscopic cytochemical method.The results showed
that there were a number of degenerated nerve terminals in the arcuate nucleus.The
characteristics of these terminals were as follows:enhanced axoplasmic electron opa-
sity,destroyed mitochondria and synaptic vesicles and the formation of dense bodies.
The multilocular forms were commonly encountered.Most of degenerated terminals
were surrouded by processes of glial cells.The degnerated perikarya of the neurons
in arcuate nucleus with decreased RER,destroyed mitochondria and dense bodies
were also observed.Based on the characteristics of degenerated features the authors
believed that these damaged terminals should mainly belong to DA fibers.They
might regulate or control the function of the arcuate nucleus by means of different
kinds of synaptic mechanisms.The source of DA nerve fibers may originate from A_(12)
A_(14) or A_(15) cell groups of the hypothalamus.
出处
《解剖学报》
CAS
CSCD
北大核心
1989年第4期373-376,共4页
Acta Anatomica Sinica
基金
中国科学院科学基金
关键词
下丘脑
弓状核
细胞化学
大鼠
电镜
Hypothalamic arcuate nucleus
6-Hydroxydopamine
Nervous dege neration Dopamine
Synapse
