摘要
本文用透射电镜观察大鼠胚胎发育中肝贮脂细胞的超微结构,并认为大鼠肝贮脂细胞来源于间充质细胞。伴随胚胎发育,贮脂细胞逐渐变小,到出生时尤为明显。10～12天胚胎肝贮脂细胞粗面内质网已发育,游离核糖体丰富,在狄氏隙内可见到胶原原纤维,说明这时贮脂细胞有合成胶原蛋白的功能。13～15天胚胎的少数贮脂细胞内有脂滴,同时可见滑面小管、吞饮现象和糖原颗粒。贮脂细胞与肝细胞之间存在桥粒连接。在16～18天胚胎,贮脂细胞与内皮细胞之间也有桥粒连接,说明贮脂细胞通过细胞连接与肝细胞和内皮细胞紧密连接。这时的贮脂细胞内还可见到微丝、微管,它们除了作为细胞骨架外,可能与调节血窦大小有关。在胚胎发育过程中,含脂滴的贮脂细胞和脂滴数量未见明显增加。
The ultrastructure of hepatic fat-storing cells in rat embryos was investigated
with transmission electron microscope.It is considered that the rat fat-storing
cells originate from mesenchymal cells.
As the embryo develops,the fat-storing cell decreases in size gradully,this is
especially obvious at the time of birth.This may be related with the function of this
type of cell.In the hepatic fat-storing cell in embryo of 10 to 12 days,the rough
endoplasmic reticulum has developed,the cell is rich in free ribosomes,and collagen
fibrils may be observed in Disse's spaces.This indicates that the fat-storing cells
have possessed the function of synthesizing collagen.In embryo of 13 to 15 days,
fat droplets appear in a few fat-storing cells and smooth endoplasmic reticulum, glycogen granules and pinocytosis may be seen at this time.It is suggested that the
function of the uptake and storage of vitamin A may appear at that time too.
There are desmosomes between the fat-storing cell and the hepatocyte.On the 16
to 18 days,desmosomes are also present between the fat-storing cell and endothelial
cell.This indicates that fat-storing cells are not free cells,but are bound to hepa-
tocytes and endothelial cells via cellular junctions,At that time,microfilaments and
microtubules are found in fat-storing cells,they are the skeleton of the cells and
they may be related to the regulation of the size of the sinusoids.In the
development of embryo,the number of fat-storing cells and fat droplets have not
increased markedly,therefore,it is thought that they are increased after birth.
出处
《解剖学报》
CAS
CSCD
北大核心
1989年第3期323-327,共5页
Acta Anatomica Sinica
关键词
贮脂细胞
超微结构
胚胎发育
肝
鼠
Fat-storing cell
Ultrastructure
Embryonic development
Liver
Rat
