摘要
目的 探讨Smad3基因对剔除小鼠血清酶活性的影响。方法 采用荷兰半自动生化分析仪对 35日龄、70日龄、6月龄的三种不同基因型的小鼠的ALP、AST、ALT、CK、LDH L进行测定。结果 纯合型小鼠各项指标较野生型高 ,且表现出ALP随着年龄的增长而降低 ;AST、ALT、CK、LDH L随着年龄的增长而增高。结论 Smad3基因的剔除对小鼠的血清酶活性有一定的影响 ,为该小鼠的进一步研究提供基础。
Objective To study the activities of the seroenzyme of the Smad3 gene knock|out mice.Methods The parameters of ALP,AST,ALT,CK,LDH|L of the 35 days,70 days and 6 months mice were measured by VITALAB made in Holland.Results The parameters of the homozygous mutation mice were the highest among that of the three gene types.ALP decreased with age,but AST,ALT,CK and LDH|L increased with age.Conclusion The activities of the seroenzymes changed due to lacking of the gene.
出处
《中国实验动物学报》
CAS
CSCD
2003年第1期12-14,共3页
Acta Laboratorium Animalis Scientia Sinica
基金
北京市科技项目专项基金 ( 95 49810 0 0 )。
