摘要
目的 :观察托吡酯治疗小儿癫痫的疗效和耐受性。方法 :确诊为小儿癫痫 5 9例 ,2 6例采用托吡酯加用、转换为单药治疗 ;2 2例单药治疗 ;11例由传统抗癫痫药 (AEDs)转换为托吡酯联合用药治疗。经 1～ 8周的加量期和 8周稳定期的观察 ,进行疗效、耐受性的评价。结果 :托吡酯治疗小儿癫痫总有效率 74 .5 8% (44 / 5 9)。单药治疗有效率 81.2 5 % (39/ 4 8) ;联合治疗有效率 4 5 .4 5 % (5 / 11)。托吡酯治疗小儿癫痫目标剂量 :2 .5～ 16mg·kg-1·d-1.平均 5 .6mg·kg-1·d-1。结论 :托吡酯抗癫痫有效 。
Objective: To observe the effects and tolerance of TPM on treating child with epilepsy.Methods: 59 children confirmed epilepsy were investigated. Among 59 cases, 26 were given TPM combined with AEDs first and then TPM only. 22 were gicen TPM only. 11 were gicen traditional fdug AEDs first and TPM combined with other AEDs followed. After 1～8weeks finducing course and 8weeks maintaining course, the therapeutic effects and tolerance of TPM were evaluated.Results: The total effect of TPM is 74.58%(44/59). The effective rate of TPM used only is 81.25%(39/48) and the 45.45%(5/11) by combined therapy. The effective does of TPM is 2.5～16mg·kg -1 ·d -1 and average 5.6mg·kg -1 ·d -1 .Conclusion: According investigation, 44 children about 74.58% achieved effecting and well tolerated by administration of TPM.
出处
《中国临床医学》
2003年第5期695-696,共2页
Chinese Journal of Clinical Medicine
