摘要
目的 探讨环氧合酶 2 (COX 2 )在胃癌组织中的表达及其临床意义。方法 应用SP免疫组织化学方法检测 47例胃癌及 1 6例正常胃组织中COX 2的表达及其与幽门螺杆菌在胃癌组织中感染的关系。结果 正常胃组织中未见COX 2表达 ,胃癌组织中COX 2表达阳性率为 63 .8% (30 / 4 7) ,其阳性表达与肿瘤的TNM分期及淋巴结转移相关(P<0 .0 1 ) ,幽门螺杆菌感染阳性组中COX 2表达阳性率为 72 .4% (2 1 / 2 9) ,显著高于幽门螺杆菌阴性组的 50 .0 %(9/ 1 8) ,P =0 .0 2。结论 COX 2的表达参与胃癌的发生及恶性进展 ,COX
Objective To study the expression of cyclooxygenase 2 (COX 2) and its clinical significance in gastric carcinoma. Methods The expression of COX 2 in 47 cases of gastric carcinoma and 16 cases of normal gastric tissue were detected by SP immunohistochemical technique. Helicobacter pylori (H.pylori) infection was diagnosed by urease experiment and Giemsa staining.Results There was no positive signal of COX 2 detected in normal gastric tissue. The positive expression rate of COX 2 was 63.8%(30/47) in gastric carcinoma.The expression of COX 2 was correlated with TNM stage, lymph node metastasis and H.pylori infection( P <0.01). Positive COX 2 expression rate in H.pylori infection group was 72.4%(21/29), significantly higher than that in the group without H.pylori infection.Conclusion COX 2 expression is involved in the carcinogenesis and malignant progression of gastric carcinoma.The examination of COX 2 may be helpful to judge biological behavior of gastric carcinoma.
出处
《中国普外基础与临床杂志》
CAS
2003年第2期137-139,共3页
Chinese Journal of Bases and Clinics In General Surgery
基金
中科院西部之光项目 (项目编号 2 0 0 0 0 132 )
