摘要
A new method is introduced to study the action between biomaterials and organism.By using an LKB-2277 bioactivity monitor and ampoule method,the fundamental thermogenesis curves of the metabolic process of pk-15 and the toxic effect of three kinds of selenomorpholine compounds on it were studied at 37℃.From the thermogenesis curves,the heat released by pk-15 metabolism was calculated.The results show that the selenium compounds all have toxic action on the metabolism process of pk-15 at the range of experimental concentrations.The sequence of the toxic action of selenium compounds is:Na_(2)SeO_(3)>β-(N-selenomorpholine)-ethyl phenyike-tone hydrochloride>selenomorpholine.
基金
Natural Science Foundation of China(29973030 and 30170010)
