摘要
本文利用我院在国内首先建立的人尿Tamm-Horsfall糖蛋白(THP)放免测定方法对肾脏病患者111例进行检测,发现急、慢性肾衰尿THP值降低最显著,其次为原发性肾小球疾病、狼疮性肾炎;肾病综合征轻度降低;紫癜性肾炎、尿路感染与正常人无差异。肾脏疾病中内生肌酐清除率(Ccr)<50ml/min的患者与尿THP呈正相关;Ccr51～75ml/min与尿THP呈非常显著负相关,Ccr>75ml/min与THP无相关性。组织学分型的尿THP分析显示了肾脏远曲肾小管的病损程度。
Urinary Tamm-Horsfall protein (THP) was measured in 111 patients with various kidney diseases,by using RIA method which was modified by our department.Results as follows:(1)The greatest decrease of urinary THP was observed in those patients with acute or chronic renal failure.Decreased amount of THP was also found in patients with primary kidney diseases and lupus nephritis,but when the patients had clinical signs of nephrotic syndrome,urinary THP was only slightly lower than normal.In patients with purpura nephritis and urinary tract infection,urinary THP was in normal range.(2)There was a positive correlation between /THP and Ccr when Ccr was less than 50 ml/min.But when Ccr was 51-75ml/min,a negative correlation was observed.No correlation could be found in patients whose Ccr was over 75ml/min.(3)The levels of urinary THP eould reflect the severity of distal renal tubule lesions in pathologically proved cases.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1989年第4期271-274,共4页
Medical Journal of Chinese People's Liberation Army
