摘要
To explore the significance of interferon gamma(IFN-γ) and adenosine deaminase (ADA)in differential diagnosis of pleural effusions. Methods: Levels of IFN-γ was measured by enzyme-linked immunosorbent assay, ADA activity was measured by colorimetric method. 37 patients with tuberculous pleural effusion and 36 patients with non-tuberculous pleurai effusions including 25 patients with malignant pleural effusions and 8 patients with pleural transudates were studied. Results: The levels of IFN-γ in patients with tuberculous pleural effusions(490.83±384.67 pg.mL^-1) were higher than those with malignant pleural effusions(36.40±90.85 pg. mL^-1) and pleural transudates(14.87±5.96 pg. mL^-1) (P<0.01). Mean ADA activity was 52.69±17.78 U. L^-1 in tuberculous pleural effusion; 19.53±13.59 in malignant pleural effusions; 9.43±4.06 inpleural transudates. The difference is significant (P<0.001). The diagnostic sensitivity of IFN-γ for tuberculous pleural effusions is 81%, specifity is 97%, the over accuracy is 90.4%. The diagnostic efficiency of ADA as following: sensitivity 89%, specifity 97%, and the over accuracy 94.5%. Conclusions: Assessments of IFN-γ and ADA in pleural effusions are of clinically diagnostic value in distinguishing tuberculous from non-tuberculous pleural effusions.
出处
《世界感染杂志》
2001年第3期199-202,共4页
World Journal of Infection
