摘要
目的 探讨严重急性呼吸综合征 (SARS)患者细胞免疫功能的动态变化及探讨免疫功能与病情进展的关系。方法 选择急性SARS患者 10 7例 ,按照疾病预后分成死亡组和治愈组 ,回顾性分析免疫功能的动态变化及免疫功能在两组间的差异。结果 SARS患者免疫功能在极期下降到最低点 ,呈现一过性免疫缺陷 ,此后迅速恢复。死亡组与治愈组比较 :疾病初期和进展期的细胞免疫功能差异无显著性 (P >0 .0 5) ,两组的CD3 +、CD4+、CD8+在病初和进展期分别为 63 9.14± 2 87.0 8/62 8.63± 3 16.85,2 95.57± 191.0 1/ 3 3 3 .3 3± 188.64,3 0 0 .71± 10 6.76/ 2 51.85± 12 5.92 ,63 5.0 0±449.50 / 790 .0 3± 558.3 0 ,3 72 .0 0± 3 0 3 .3 7/ 4 17.0 9± 3 12 .0 4,2 52 .71± 14 7.44/ 3 3 8.43± 3 0 0 .3 6;极期和恢复期的细胞免疫功能差异非常显著 (P <0 .0 1) ,死亡组和治愈组在极期与恢复期的CD3 +、CD4+、CD8+分别为 3 0 4.0 0± 84.2 6/ 70 1.97± 489.43 ,171.11± 78.84/ 3 99.41± 3 3 2 .40 ,13 3 .2 2±2 4.3 1/ 2 87.71± 199.88,3 4 9.50± 183 .84/ 112 0 .2 9± 565.42 ,2 0 2 .0 0± 10 1.89/ 645.12± 3 76.3 3 ,13 9.79± 87.0 7/ 4 53 .0 9± 2 51.0 6。结论 SARS确实影响机体免疫功能 ,大?
Objective To discuss the relationship between disease progress with the change of cell im munological function as well as the effect of immunological function in severe a cute respiratory syndrome. Methods Retrospective study was designed to analyze the relationship of disease progres s with the change of immunological function. According to the disease outcomes, the patients are divided into two groups: died group and survival group. The dif feren ce of immunological function in groups was performed statistics analysis. Results Immunological function (CD3 +, CD4 +, CD8 +) descended to the lowest level in period of fastigium in SARS patient, and then recovery quickly. Comparison of died grou p and survival group was found that Immunological function (CD3 +T, CD4 +T, CD 8 +T) were lower in period of fastigium and recovery in died group than in survival g roup(P <0.001 ). Conclusion Immunological function was affected by SARS infec tion, but transiently in most cases. Only a minor of dead cases displayed irreve rsible inhibition of immune function.
出处
《中华传染病杂志》
CAS
CSCD
北大核心
2003年第5期334-337,共4页
Chinese Journal of Infectious Diseases
