摘要
目的 :研究血浆同型半胱氨酸 (Hcy)水平 ,探讨高同型半胱氨酸血症与深静脉血栓 (DVT )形成的关系。方法 :采用荧光偏振免疫法 (FPIA)测定 78例深静脉血栓病人和 95例健康对照者的血浆同型半胱氨酸 (Hcy)水平。结果 :空腹状态深静脉血栓组血浆同型半胱氨酸水平为 (13 .1± 7.6) μmol L ,明显高于对照组 (10 .6± 4.2 ) μmol L(P <0 .0 5)。蛋氨酸负荷试验后深静脉血栓组血浆同型半胱氨酸水平为 (41.6± 14 .8) μmol L ,显著高于对照组 (3 5.3± 13 .9) μmol L(P <0 .0 5)。轻中度升高的血浆同型半胱氨酸水平增加了深静脉血栓形成的危险性 (禁食后比数比OR =2 .995%CI 1.1～ 9.7;蛋氨酸负荷试验后比数比OR =3 .595%CI 1.3～ 10 .8)。结论 :血浆同型半胱氨酸水平与深静脉血栓形成密切相关 ,高同型半胱氨酸血症 (HHcy)
Objective:To assess the relationship betw een hyperhomocysteinemia and deep-vein thrombosis, plasma homocystein e levels in patients with deep-vein thrombosis and in normal control subjects were studied. Methods: In 78 patients with DVT and 95 health y controls the plasma hemocysteine levels were measured by fluorescence polariza tion immunoassay (FPIA). Results: The plasma h omocysteine level was significantly higher in DVT group than in control in the fasting state [ (13.1±7.6)μmol/L vs(10.6±4.2)μmol/L, P <0.05]; The plasma homocysteine l evel was significantly higher in DVT group than in control after methionin e loading [( 41.6 ±14.8)μmol/L vs (35.3±13.9)μmol/L, P <0.05]. The o dds ratio (OR) of mild hyperhomocysteinemia for DVT in the fasting state is 2.9 (95% CI 1.1-9.7),and after methionine loading is 3.5 (95% CI 1.3-10.8). Conclusion: DVT is highly correlated with Hcy concentration. Hyperhomocysteinemia is a risk factor for deep-vein thrombosis in the general population.
出处
《江苏大学学报（医学版）》
CAS
2003年第5期408-410,共3页
Journal of Jiangsu University：Medicine Edition
