摘要
目的 评价曲美他嗪治疗稳定型心绞痛合并糖尿病疗效。方法 选取 10 3例稳定型心绞痛合并糖尿病病人 ,其中男 72例 ,女 31例 ,年龄 4 6～ 72岁 ,平均 ( 5 9±11 8)岁 ,常规服用曲美他嗪 2 0mg每天 3次 1个月 ,在此之前及 1个月后进行病史询问、生化检查及活动平板检查。结果 全部病人完成随访 ,1例服药后有轻微上腹部不适 ,1例便秘 ,无需停药。每周心绞痛发作次数从 ( 8 8± 3 9)次减少为( 4 5± 2 9)次 (P <0 0 1) ,硝酸甘油消耗量减少 ( 5 0±2 7)片减少至 ( 3 1± 1 9)片 (P <0 0 1)。活动平板运动持续时间从 ( 2 12 1± 5 4 3)s增加至 ( 2 76 3± 5 4 1)s ,运动耐量从 ( 84 2± 8 9) %增至 ( 95 6± 4 3) % (P <0 0 1) ,运动至ST段下移 1mm的时间 ( 176 4 3± 4 7 2 )s延长至 ( 2 4 3 78±5 1 9)s(P <0 0 0 1) ,运动至ST段压低的最大幅度从 ( 2 2±0 6 )mm减少至 ( 1 7± 0 7)mm(P <0 0 0 1)。结论 在传统血流动力学药物治疗的基础上联用曲美他嗪 ,可以使稳定型劳力型心绞痛合并糖尿病患者的心绞痛症状减轻 ,运动耐量增加 ,且安全性好。
Objectives To evaluate the therapeutic efficacy of trimetazidine in patients with stable angina pectoris and diabetes. Methods A total of 103 diabetic patients with stable angina (male 72, female 31, age 46～72) were studied from March 1999 to March 2002. All patients were received a stabilization, 4 week therapy with trimetazidine, 20 mg three times daily, in combination with previous treatment. Some clinical data included blood examination and treadmill exercise tests were compared before and after 4 weeks. Results All patients were completed the follow up. There were somewhat stomachache sometimes in one case and constipation in one patient. No one stopped the therapy within the study. During the follow up, the times of the anginal attacks in every week decreased (8 8±3 9 vs 4 5±2 9, P <0 01), the consumptions of nitroglycerine pills reduced (5 0±2 7 vs 3 1±1 9, P <0 001). The data of the treasmill exercise showed a significant improvement in exercise tolerance (84 2%±8 9% vs 95 6%±4 3%, P <0 01),time to 1 mm ST segment depression (176 43±47 2 vs 243 78±51 9; P <0 01). The total times of exercise was increased (212 1±54 3 vs 276 3±54 1, P <0 001). Maxiaml ST segment depression was decreased (2 2±0 6 vs 1 7±0 7, P <0 001). Conclusion In the base of traditional haemodynamic medical therapy, trimetazidine lightened the anginal symptom in stable angina pectoris combined with diabetes. It can increased the exercise tolerance. Trimetazidine had good security and tolerance.
出处
《岭南心血管病杂志》
2003年第5期347-348,共2页
South China Journal of Cardiovascular Diseases
