摘要
目的 探讨小剂量米非司酮对子宫内膜异位症的疗效。方法38例子宫内膜异位症患者,于月经周期第1天开始服用米非司酮10mg,每日1次,连续服用6个月观察临床疗效及生殖激素的改变。结果 服药期间所有患者均闭经,痛经及盆腔痛消失,腺肌症患者子宫明显缩小,卵巢异位囊肿缩小或消失。雌二醇(E2)及孕酮(P)处于早-中卵泡期水平。结论 小剂量米非司酮长期服用可破坏子宫内膜的完整性,干扰其功能,影响在位及异位内膜的生物学效应,从而起到治疗子宫内膜异位症的作用。尤其适用于围绝经期及术后复发的子宫内膜异位症的治疗。
Objective To study the effects of low dose mifelpristone on the treatment of endometriosis. Methods 38 patients with endometriosis were given mifelpristone 10mg per day within a period of 6 months. Clinical effects and the level of E2 and P were observed. Results Amenorrhea happened in all patients, pelvic pain disappeared. The uterine volume reduced. Ovary chocolate cysts reduced or disappeared. E2 and P were at lower level. Conclusions Mifelpristone has good effects on the treatment of endomeriosis,especially for the peri-menopausal women with endometriosis and for patients pre-operation and post-operation.
