摘要
目的 探讨丙型肝炎患者 m IL - 2 R表达水平及其临床意义。方法 用生物素 -链酶亲和素法对 5 6例抗 - HCV阳性患者外周血单个核细胞 (PBMC)进行植物血凝素 (PHA )诱导前后 m IL - 2 R的的检测。结果 急、慢性丙型肝炎患者静息状态 m IL - 2 R表达水平 ,诱导状态 m IL - 2 R表达水平分别与正常对照相比 ,差异均有显著性。结论 丙型肝炎患者体内存在明显的细胞免疫功能紊乱 ,T细胞活化障碍 ,并与肝病的慢性化有关。
Objective To study the expressive level of mIL-2R in peripheral blood mononuclear cells (PBMC) of patients with hepatitis C and its significance. Methods The level of mIL-2R on surface of PBMC was detected with biotin-streptavidin technique before and after PHA induction for patients with positive anti-HCV. Results There were significantly difference between level of mIL-2R before and after PHA induction in blood of patients with acute and chronic hepatitis C. Conclusions The function of cellular immunity and T cells were obvious in disorder for patients with hepatitis C, and they were associated with chronicity of hepatitis.
出处
《疾病控制杂志》
2003年第5期431-432,共2页
Chinese Journal of Disease Control and Prevention
