摘要
目的 探讨同步放疗、化疗治疗中晚期宫颈癌的疗效及毒副作用。方法 将病理确诊的Ⅱb期～Ⅳ期宫颈癌 43例作为研究组 (A组 ) ,DDP 5 0mg/m2 合并水化 ,第 1天 ;5 Fu 75 0mg/m2 ,静脉点滴 ,第 2～ 5天 ;4周重复 1次 ,共 2～ 4次。同时行根治性放疗 ,60 Co体外照射 ,总剂量为 45～ 5 0Gy ,腔内后装采用192 Ir后装机 ,A点 7Gy/周 ,总剂量为 3 5～ 42Gy。以同期收治、条件相同行单纯放疗的 40例宫颈癌患者为对照组 (B组 )。观察近期疗效、3年生存率及放疗、化疗并发症。结果 放疗 3个月后 2组有效率分别为 93 .0 % (A组 )和 72 .5 % (B组 ) ,有显著性差异 (P <0 .0 5 )。A组 3年生存率 (83 .7% )明显高于B组 (62 .5 % ) ,P <0 .0 5。A组局部复发率、远处转移率明显低于B组。同步放疗、化疗组有较明显的骨髓抑制、消化道反应 ,但均能耐受。放疗远期并发症不增加。结论 同步放疗、化疗能明显提高中晚期宫颈癌患者的生存率 ,DDP + 5 Fu的应用是安全可行的 。
Objective To investigate the curative effect and side effect of synchronous radiochemotherapy in medium-term and advanced cervical carcinoma.Methods The treatment group(group A) included 43 pathologically verified cases of stage Ⅱb～Ⅳ cervical carcinoma.Each patient was given DDP with hydration at the dose of 50 mg/m 2 intravenously at the first day and 5-Fu 750 mg/m 2 daily intravenously from the second day to the fifth day.The treatment cycle was performed once every 4 weeks for 2～4 times.Radiotherapy was given at the same time. 60Co was used for external radiation with a total dose of 45～50 Gy. 192Ir afterloading unit was used for brachytherapy at the dose of 7 Gy per week at point A with a total dose of 35～42 Gy.The control group(group B) included 40 cases of cervical carcianoma at the same stage in the corresponding period who received radiotherapy only.Short-term effect,3-year survival rate and complications were observed.Results Effective rate was 93.0% in Group A and 72.5% in Group B respectively 3 months after radiotherapy,showing a significant difference(P<0.05).3-year survival rate was higher in Group A (83.7%) than in Group B(62.5%)(P<0.05).Local recurrent and distant metastasis were lower in Group A than in Group B.In group A,there were tolerable bone marrow inhibition and reaction of digestive tract without additional long-term complications.Conclusion Synchronous radiotherapy and chemotherapy can remarkably increase the survival rate of medium-term and advanced cervical carcinoma.The application of DDP and 5-Fu is effective and safe,but the long-term effect needs further observation.
出处
《实用癌症杂志》
2003年第5期533-535,共3页
The Practical Journal of Cancer
关键词
宫颈癌
放疗
化疗
疗效观察
治疗
Cervical carcinoma
Synchronous radiotherapy and chemotherapy
Survival rate
Complications
