摘要
目的探讨平原地区官兵进驻高原地区后骨代谢变化。方法采用UBIS 30 0 0型定量超声仪 ,对 1 1 5名官兵跟骨进行定量超声测定 ,同时用化学发光免疫法测定尿脱氧吡啶酚 (DPD)排泄浓度。将进驻高原地区 2个月后的测定结果与返回平原 2个月后的测定结果进行对比分析。结果进驻高原地区官兵跟骨超声振幅衰减 (BUA)、超声声速 (SOS)和刚度 (STI)各年龄段均较返回平原组显著降低 (P <0 .0 1 )。尿DPD排泄浓度高原组 2 0岁以下和 2 1～ 30岁年龄段分别为 (2 1 0 .79± 78.6 9)nmol·L 1和 (4 1 6 .995± 33.80 )nmol·L 1高于平原组的 (1 34.5 1± 98.96 )nmol·L 1和 (1 2 1 .2 0± 6 6 .87)nmol·L 1(P <0 .0 1 ) ,30～ 4 0岁和 4 0岁以上年龄段也有差异 (P <0 .0 5 )。结论平原地区官兵进驻高原 2个月后 ,因受高原缺氧等因素的影响 ,可导致骨代谢异常 ,骨吸收增加。提示 ,进驻高原地区前应及时进行预防治疗 ,避免骨质疏松的发生。
Objective To study the changes of bone density and metabolism index in soldiers and officers stationed at altitude and after returned to plain. Methods Calcaneal quantitative ultrasound (QUS) were measured using UBIS 3000 QUS instrument and the concentration of urine deoxypyridinoline (DPD) was assayed by enzyme linked immunosorbent in 115 soldiers and officers stayed at altitude for 2 months. The same procedures were carried out 2 months after they returned to plain. Results The values of calcaneal broadband ultrasound attenuation (BUA), speed of sound (SOS) and stiffness (STI) in altitude group were significantly lower than those in plain group at any age (P<0.01). Urine DPD concentrations at the age of <20 and 21～30 in altitude group〔( 210.79±78.69 )nmol·L 1 ,( 416.99±33.80)nmol·L 1 respectively〕 were higher than those in plain group〔(134.51±98.96)nmol·L 1 ,(121.20±66.87)nmol·L 1 respectively,P<0.01〕. There were also differences between the two groups at the age of 31～40,>41 (P<0.05). Conclusion The influence of hypoxia at altitude and other factors may result in abnormality in bone metabolism and increase of bone resorption. Osteoporosis in the soldiers and officers should be prevented before station at altitude.
出处
《解放军预防医学杂志》
CAS
北大核心
2003年第5期337-339,共3页
Journal of Preventive Medicine of Chinese People's Liberation Army
基金
"十五"全军重大课题项目 (No.0 .1Z0 18)
关键词
高原
跟骨
定量超声
DPD
骨质疏松
altitude
calcaneus
quantitative ultrasound
deoxypyridinoline
osteoporosis
