摘要
目的 利用3 1P磁共振波谱评价心肌梗死后心肌能量代谢的变化 ,区分存活心肌与梗死心肌。方法 对 10例证实为前壁心梗的患者 ,CABG(coronaryarterybypassgrafting)治疗术前 ( 2～ 8天 )及术后 ( 4～ 6个月 )行电影MRI和3 1PMRS检查 ,检测前壁心肌PCr、ATP、Pi ,并计算PCr/γ ATP、PCr SNR及γ ATP SNR ,确定前壁心肌节段心功能恢复情况 ,观察梗死前壁节段心肌3 1PMRS检测高能磷酸盐变化与心肌活力的关系。对照组 10例志愿者参加研究。结果 前壁心肌梗死后存活心肌 ( 7例 ) 3 1PMRS显示PCr SNR和γ ATP SNR与健康志愿者比较无显著差异 (P >0 .0 5 )。MRI检测无活力心肌 3例 ,3 1PMRS基本未测出PCr峰且γ ATP SNR与健康志愿者比较显著减低 (P <0 .0 5 )。结论 3 1P磁共振波谱可用于评价心肌梗死后心肌能量代谢的变化 ,是非侵入性心肌高能磷酸盐监测的有利工具。
Objective To investigate the change in myocardial infarction by 31 P MR spectroscopy, and to distinguish the viable myocardium from the infarct myocardium. Methods Ten patients with anterior myocardial infarction performed cine MRI and 31 P MRS (using 2D CSI technique) before and after coronary artery bypass grafting, and adenosine triphosphate (ATP), phosphocreatine (PCr), and inorganic phosphate (Pi) of the anterior myocardium were measured, and PCr/γ ATP, PCr SNR, and γ ATP SNR were calculated. The relationship between the changes of high energy phosphates measured by 31 P MRS and the viability of infarct myocardium was observed. Results The 31 P MRS of the viable myocardium showed that PCr SNR and γ ATP SNR had no significant difference compared to 31 P MRS of normal myocardium of healthy volunteers ( P >0.05). PCr peak of the non viable anterior myocardium could not be detected, and γ ATP SNR significantly reduced compared with that of normal myocardium ( P <0.05). Conclusion 31 P MRS can be used to evaluate the changes of myocardial energy metabolism after infarction. It is a noninvasive tool in assessing the human myocardial energy metabolism. [
出处
《中国医学影像技术》
CSCD
2003年第9期1128-1130,共3页
Chinese Journal of Medical Imaging Technology
关键词
磁共振波谱
存活心肌
能量代谢
Magnetic resonance spectroscopy
Viable myocardium
Energy metabolism
