摘要
目的 研究 β 七叶皂甙钠联合地米在食管癌后程加速放疗中的应用价值。 方法 放疗 :食管癌予后程加速放疗 ,先常规分割,照射 4周 2 1次至 42Gy后缩野改加速超分割 ,2次 /天 ,1 5Gy/次 ,总量为 6周 3 9次 69Gy。用药 :于后程加速放疗开始即予药物治疗。结果 用药组与对照组急性放射性食管炎及气管炎发生率分别为 :3 3 3 %、5 9 4% (χ2 =4 43 3 ,P =0 0 3 5 )和 15 2 %、3 7 5 %(χ2 =4 2 0 1,P =0 0 40 ) ,其组间差别有统计学意义。两组治疗后 1月其急性放射性食管炎及气管炎的发生率分别下降为 :15 2 %、3 7 5 % (χ2 =4 2 0 1,P =0 0 4)和 12 1%、3 4 4% (χ2 =4 5 3 2 ,P =0 0 3 3 ) ,其差别亦有统计学意义。在减轻放射性肺纤维化等晚反应方面两组相似。结论 在食管癌后程加速超分割治疗中 ,应用 β 七叶皂甙钠联合地米能减轻放疗急性反应并缩短反应持续时间 ,对放射性肺纤维化等晚反应无价值。
Objective To evaluate the effect of β-escin combined with dexamethasone in esophageal carcinoma treated by LCAHR.Methods Of the 65 patients with esophageal carcinoma treated by LCAHR,33 were subjucted to receive β-escin combined with dexamethasone, and 32 were given conventional treatment.Results The probability of acute esophagitis and trachitis were 33.3%,15.2% in conbination group and 59.4%,37.5% in control group, There was a statistical difference( χ 2=4.433 ,P=0.035; χ 2=4.201,P=0.040 ).The acute esophagitis and trachitis treated 1-month later were 15.2%,12.1% in the former and 37.5%,34.4% in the latter, The differences were significant( χ 2=4.201,P=0.04; χ 2 =4.532,P=0.033 ).It was similar to the two groups in late reaction to radioactive pulmonary fibrosis.Conclusions In LCAHR,β-escin natrium may be used in combination with dexamethasone to relieve acute reaction to radiation and to shorten the duration of the reaction.It was no value for the relief of late reaction to radioactive pulmonary fibrosis.
出处
《河南肿瘤学杂志》
2003年第5期346-347,共2页
Henan Journal of Oncology
