摘要
目的 评价促红细胞生成素在脊柱外科围手术期应用的临床意义和安全性。方法 对两组条件相似的需脊柱手术患者共 30例进行随机配对的前瞻性研究。其中治疗组于手术前 7d开始使用重组人促红细胞生成素 (rhEPO)。采用 10 0 0 0IU/次 ,皮下给药 ,隔日 1次共两周。对照组不给予rhEPO处理 ,其他处理同治疗组。将两组的检测结果进行研究分析。结果 两组间Ret ,Hb ,Hct手术后有明显差异 ,而生命体征 ,Plt无明显差异。结论 在手术前应用rhEPO进行人红细胞动员 ,可促进红细胞的发育和生成 ,并提高Hb的含量 ,减少输血的机会 ,并且未发现有明显与其相关的不良反应。
Objective To determine the clinical significance and safety of rhEPO applied in spinal operation. Methods 30 patients(15 couples) of 2 groups who were admitted for spinal operation were examined in a prospective controlled study. The experimental group(15 cases) received rhEPO before operation,and the control group(15 cases) did not. The Ret,Hb,Hct and Plt were recorded for analysis. Results There were significant differences in Ret,Hb and Hct between 2 groups after operation and no significant differences in plt. Conclusion Preioperative erythrocyte mobilization by rhEPO can promote the production of Ret and upgrade the level of Hb and reduce the chance of transfusion. There is no related side reaction.
出处
《四川医学》
CAS
2003年第10期1025-1027,共3页
Sichuan Medical Journal
