摘要
本文对35例慢性阻塞性肺疾病(COPD)急性加重期AT-Ⅲ:Ag和FN的关系作出评价。21例AT-Ⅲ:Ag降低(<22.96mg％)。10例FN降低(<185μg/ml),FN降低者其AT-Ⅲ:Ag值均降低。FN降低者和正常者其AT-Ⅲ:Ag分别为12.45±2.86mg％和22.23±4.87mg％(P<0.01)。AT-Ⅲ:Ag和FN值间有一定相互关系(r=0.61 P<0.01)。认为在老年COPD急性加重期,炎症、低氧血症和高碳酸血症促使血栓前状态发生和发展,并形成恶性循环;AT-Ⅲ:Ag可作为早期预测血栓前状态的客观指标。
The correlation between infection and prothrombogenesis has not been assessed in acute exacerbation of chronic obstructive pulmonary disease (COPD) in elderly person. We have evaluated AT-Ⅲ: Ag and fibronectin (Fn) in 35 patients (age 72±8 years) with clinical evidence of exacerbation (PaO_2 7.4±1.1kPa). AT-Ⅲ: Ag was found decreased (<22.96 mg%) in 21 patients, and Fn decreasd (<185μg/ml) in 10 patients. AT-Ⅲ:Ag was decreased in all patients (n=10) in whom Fn was decreased. The values of AT-Ⅲ:Ag were 22.23±4.87mg% and 12.45±2.86 mg% respectively in patients with normal level and decreased level of Fn (P<0.01). There was a significant correlation between the values of AT-Ⅲ:Ag and Fn (r 0.61 P<0.01). It is thus concluded that during acute exacerbation of COPD in elderly persons, inflammation, hypoxemia, and hypercapnia provoke the development of prethrombogenesis state which induces the vicoous circle, and AT-Ⅲ:Ag is the objective indicator for early detection of widespread prethrombogenesis state.
出处
《上海医学》
CAS
CSCD
北大核心
1992年第11期636-638,共3页
Shanghai Medical Journal
关键词
阻塞性肺疾病
纤维连接蛋白
COPD
Chronic obstructive pulmonary disease
antithrombin Ⅲ:Ag
fibronectin
