摘要
以电刺激内脏大神经或耳尖部皮肤测定清醒家兔内脏或皮肤痛阈,观察中脑导水管周围灰质(PAG)中阿片肽和去甲肾上腺素在内脏镇痛和皮肤镇痛中的作用。结果:PAG内微量注射α受体阻断剂酚妥拉明(5μg/μl),皮肤痛阈明显升高,并增强和延长电针镇皮肤痛,但内脏痛阈无明显变化。微量注射β受体阻断剂普萘洛尔(5μg/μl),内脏痛阈和皮肤痛阈均无变化。PAG内微量注射阿片受体激动剂依托啡(1 μg/μl)后,内脏痛阈及皮肤痛阈明显上升,且可被纳洛酮(0.4mg/kg)iv所翻转。提示PAG内去甲肾上腺素α受体参与皮肤痛的调制,而阿片肽参与皮肤痛和内脏痛的调制。
The present work revealed: (1) After mioroinjeotion of α-antagonist phentol-amine (5μg/μl) into the periaqueduotal gray (PAG), the somatic pain threshold was raised, whtereas the visceral pain threshold remained the same. The mioroinjeotion enhanced the effect of electroaoupunoture (EA) on somatic pain and prolonged the after-effect. (2) After microinjection of etorphine (μg/μl) into the PAG, the visceral pain threshold and somatic pain threshold increased remarkably, and naloxone (0.4mg/kg, iv) antagonised the effects.
出处
《上海医科大学学报》
CSCD
1992年第4期241-245,共5页
Journal of Fudan University(Medical Science)
基金
国家教委博士点基金
关键词
中脑
苯妥安
心得安
依托啡
止痛
periaqueductal gray (PAG)
visceral ain
somatic pain
phentolamine
propranolol
etorphine
