摘要
目的 :通过检测 2型糖尿病 ( T2 DM)患者血清可溶性细胞间粘附分子 - 1 ( Soluble intercellularadhesion mo1 ecule- 1 ,s ICAM- 1 )、血浆血栓调节蛋白 ( P1 asma thrombomodulin,PTM)水平变化的特点 ,探讨检测患者 s ICAM- 1、PTM的临床意义。方法 :采用 ELISA法检测了 5 8例 T2 DM患者和 30例健康对照组s ICAM- 1、PTM水平。结果 :T2 DM患者各组 s ICAM、PTM检测结果 (单位μg/L ) :T2 DM组为 2 2 0 .0±32 .8,33.9± 1 3.7;有并发症组为 2 77.9± 2 5 .6,36.9± 8.6;无并发症组为 2 0 4 .7± 1 8.1 ,2 8.1± 9.1。对照组为 1 88.6± 1 6.9,2 0 .1± 7.8。 T2 DM患者 s ICAM- 1、PTM水平变化特点 :1 T2 DM患者血 s ICAM- 1、PTM水平显著高于对照组 ( P<0 .0 1 ) ;2 T2 DM有并发症患者 s ICAM- 1、PTM水平显著高于无并发症患者 ( P<0 .0 1 ) ;3无并发症患者与对照组患者相比有显著性 ( P<0 .0 1 )。结论 :T2 DM患者存在血管内皮损伤 ,患者体内存在 s ICAM- 1、PTM的异常表达 ,与患者病情呈正相关 ,s ICAM- 1、PTM可能是 T2
Objective:To explore the clinical significance of sICAM 1 and PTM in T 2 DM patients by examining their serum levels.Methods:The study was undertaken to detect serum sICAM 1,PTM levels in 88 cases including 58 T2 DM patients and 30 healthy controls by using sanduich enzyme linked immuno sorbent assay.Results:The results of each T2DM patients group were following standard mg/L.In T2DM group they were 220±32 8 and 32 9±13 7 respectively,those of T2DM patients with complications were 227 9±25 6 and 36 9±8 6,those without complicaions were 204.7±18 1 and 28 0±9 1.Those of control group were 188 6±16 9 and 20 1±7 8.The characteristics of SICAM and PTM in T2DM patients were ①the SICAM 1 and PTM levels of T2DM patients were signicantly higher than those of healthy controls ( P <0 01);②the levels of T2DM patients with complications were significantly higher than those of T2DM patients without complications (P <0 01);③there were important difference between the levels of patients without complications and those of healthy controls ( P <0 01).Conclusion:There are uasculer endotholial cells hurot and then serum SICAM 1 and PTM abnormally express which are possitively relative to patients condition,so sICAM 1 and PTM may be the early menitoring mark when T2DM patients have complication.
出处
《滨州医学院学报》
2003年第6期417-419,共3页
Journal of Binzhou Medical University
关键词
2型糖尿病
可溶性细胞间粘附分子-1
血栓调节蛋白
type I diabetes mellitus
soluble intercellular adhesion molecules,plasma thrombomodulin
