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丙基硫氧嘧啶和ANCA阳性血管炎 被引量:8

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摘要 丙基硫氧嘧啶(PTU)是治疗Graves病最常用的药物,近年来不断有报道提示在用PTU治疗的病人中出现 抗中性粒细胞胞浆抗体(ANCA),并可导致自身免疫性血管炎。临床多表现为全身系统受累,肾脏是最易受累的器 官,肾外最常见的是肺脏、皮肤、粘膜,还可表现为狼疮样综合征。本病的预后与病程有关,及时停药是关键。
出处 《国外医学(内分泌学分册)》 2003年第6期388-390,共3页 Foreign Medical Sciences(Section of Endocrinology)
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参考文献13

  • 1徐旭东,赵明辉,章友康,郭晓惠,王海燕.丙基硫氧嘧啶导致的抗中性粒细胞胞质抗体阳性小血管炎及其靶抗原研究[J].中华内科杂志,2002,41(6):404-407. 被引量:54
  • 2姚斌,翁建平,胡国亮,余学清,姜傥,黄锋先.丙基硫氧嘧啶致血管炎一例[J].中华医学杂志,2002,82(10):677-677. 被引量:3
  • 3Noh J Y, Asari T, Hamada N, et al. Frequency of appearance of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) in Graves' disease patients treated with propylthiouracil and the relationship between MPO-ANCA and clinical manifestations [ J ]. Clin Endocrinol (Oxf), 2001,54 : 651-654.
  • 4Sera N, Ashizawa K, Ando T, et al. Treatment with propylthiouracil is associated with appearance of antineutrophil cytoplasmic antibodies in some patients with Graves' disease[J]. Thyroid,2000,10:595-599.
  • 5Gunton J E, Stiel J, Clifton-Bligh P, et al. Prevalence of positive anti-neutrophil cytoplasmic antibody(ANCA) in patients receiving anti-thyroid medication [J]. Eur J Endocrinol, 2000,142 : 587.
  • 6Wada N, Mukai M, Kohno M, et al. Prevalence of serum anti-myeloperoxidase antineutruphil cytoplasmic antibodies(MPO-ANCA) in patients with Graves' disease treated with propylthiouracil and thiamazole [ J ]. Endocr J, 2002,49 :329-334.
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  • 9Poomthavom P, Mahachoklertwattana P, Tapaneya-Olarn W, et al. Antineutrophilic cytoplasmic antibody-positive systemic vasculitis associated with propylthiouracil therapy:report of 2 children with Graves' disease[J]. J Med Assoc Thai, 2002,85 : 295-301.
  • 10Kawasaki Y, Suzuki T, Sike T, et al. A pediatric case of myeloperoxidase-antineutrophil cytoplasmic antibody (ANC A)-related crescentic glomerulonephritis associated with propylthiouracil treatmant for Graves' disease [ J ]. Neppon Jinzo Gakkai Shi,1998,40:612-617.

二级参考文献7

  • 1Zhao MH, Jones SJ, Lockwood CM. Bactericidal / permeability-increasing protein (BPI) is an important antigen for antineutrophil cytoplasmic autoantibodies (ANCA) in vasculitis. Clin Exp Immunol, 1995, 99: 49-56.
  • 2Zhao MH, Lockwood CM. Azurocidin is a novel antigen for antineutrophil cytoplasmic autoantibodies (ANCA) in systemic vascutilis. Clin Exp Immunol, 1996 , 103: 397-402.
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  • 4Miller RM, Savige J, Nassis L, et al. Antineutrophil cytoplasmic antibody (ANCA)-positive cutaneous leucocytoclastic vasculitis associated with antithyroid therapy in Graves′ disease. Australas J Dermatil, 1998, 39: 96-99.
  • 5Choi HK, Merkel PA, Walker AM, et al. Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis: prevalence among patients with high titers of antimyeloperoxidase antibodies. Arthritis Rheum, 2000, 43: 405-413.
  • 6Kitahara T, Hiromura K, Maezawa A, et al. Case of propylthiouracil-induced vasculitis associated with anti-neutrophil cytoplasmic antibody (ANCA); review of literature. Clin Nephrol, 1997, 47:336-340.
  • 7赵明辉,章友康,王海燕.加强抗中性粒细胞胞浆抗体检测方法的规范化及合理应用[J].中华内科杂志,1998,37(3):149-150. 被引量:39

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