摘要
目的：探讨Ｄ－半乳糖（Ｄ－Ｇａｌ）对小鼠脾淋巴细胞损伤的分子机理．方法：测定不同浓度Ｄ－Ｇａｌ作用后小鼠淋巴细胞乳酸脱氢酶（ＬＤＨ）、超氧化物歧化酶 （ＳＯＤ）、琥珀酸脱氢酶（ＳＤＨ）活性以及过氧化脂质（ＬＰＯ）水平．结果：与对照组比较，ＬＤＨ、ＳＯＤ和ＳＤ Ｈ活性均有显著降低（Ｐ＜０．０１），ＬＰＯ水平显著提高（Ｐ＜０．０１）．结论：Ｄ－Ｇａｌ能引起小鼠脾淋巴细胞及其功能的损伤．
Object To discuss the molecule mechanism of damage on mouse splenolymphocytes by D -galactose(D-Gal). Method The mouse spleen cells were cultivated with different density of D-Gal in vitro. Results As Compared with the control group, Lactate dehydrogenase (LDH) activity. Superoxide Dismutase (SOD) activity and Succinate dehydrogenase(SDH) of D -Gal group decreased distinctly, however, Lipid Peroxyl (LPO) increased distinctly. Conclusion D -Gal can cause peroxidate damage of mouse spleen lymphocyte and its function.
出处
《大连大学学报》
2000年第2期80-82,共3页
Journal of Dalian University
